Authors:

Joseph Weidman, Ralph E. Holsworth Jr., Bradley Brossman, Daniel J. Cho, John St.Cyr and Gregory Fridman

Publication:

Journal of the International Society of Sports Nutrition, June 2016

Summary:

A significant difference in whole blood viscosity was detected in this study when assessing a high-pH, electrolyte water versus an acceptable standard purified water during the recovery phase following strenuous exercise-induced dehydration.

Authors:

Massimiliano Magro, Livio Corain, Silvia Ferro, Davide Baratella, Emanuela Bonaiuto, Milo Terzo, Vittorino Corraducci, Luigi Salmaso, and Fabio Vianello

Publication:

Evidence-Based Complementary and Alternative Medicine, May 2016

Summary:

A 3-year survival study on a population of 150 mice was carried out in order to investigate the biological effect of alkaline water consumption. Firstly, nonparametric hazard and survival plots suggest that mice watered with alkaline water overwhelmed control mice. Secondly, data were analyzed with accelerated failure time (AFT) model inferring that a benefit on longevity, in terms of “deceleration aging factor” was correlated with the consumption of alkaline water. Finally, histological examination of mice kidneys, intestines, hearts, livers, and brains was performed in order to verify the risk of diseases correlated to alkaline watering. No significant damage, but aging changes, emerged; organs of alkaline watered animals resulted to be quite superimposable to controls, shedding a further light in the debate on alkaline water consumption in humans.

Author:

WANG Yu-lian

Publication:

Shanghai Journal of Preventive Medicine, Jan 2016

Summary:

Methods Blood pressure, blood sugar and blood lipids were assailed respectively pre-and 3 to 6 months after alkaline ionized water was drunk. Results The levels of blood pressure, blood sugar and blood lipids decreased significantly even to normal ranges after alkaline ionized water was drunk. Conclusions Alkaline ionized water may be used as one of the accessory therapeutic methods for essential hypertension, diabetes mellitus and hyperlipidaemia.

Author:

Dr. Sergej M. Ostojic

Publication:

Center for Health, Exercise and Sport Sciences, Exercise Physiology Lab, Belgrade, Serbia, Sep 2014

Summary:

In the past 2 decades, molecular hydrogen emerged as a novel therapeutic agent, with antioxidant, anti-inflammatory and anti-apoptotic effects demonstrated in plethora of animal disease models and human studies. Beneficial effects of molecular hydrogen in clinical environment are observed especially in oxidative stress-mediated diseases, such as diabetes mellitus, brain stem infarction, rheumatoid arthritis, or neurodegenerative diseases. A number of more recent studies have reported that molecular hydrogen affects cell signal transduction and acts as an alkalizing agent, with these newly identified mechanisms of action having the potential to widen its application in clinical medicine even further. In particular, hydrogen therapy may be an effective and specific innovative treatment for exercise-induced oxidative stress and sports injury, with potential for the improvement of exercise performance.

Authors:

Dr. Sergej M. Ostojic, Vukomanovic B, Calleja-Gonzalez J, Hoffman JR

Publication:

Serbian Ministry of Science, Sep 2014

Summary:

Preliminary results support the hypothesis that the addition of hydrogen to traditional treatment protocols is potentially effective in the treatment of soft tissue injuries in male professional athletes.

Authors:

Dr. Sergej M. Ostojic, Marko D. Stojanovi

Publication:

Research in Sports Medicine: An International Journal, Jan 2014

Summary:

Possible appliance of effective and safe alkalizing agent in the treatment of metabolic acidosis could be of particular interest to humans experiencing an increase in plasma acidity, such as exercise-induced acidosis. In the present study we tested the hypothesis that the daily oral intake of 2L of hydrogen-rich water (HRW) for 14 days would increase arterial blood alkalinity at baseline and post- exercise as compared with the placebo. These results support the hypothesis that HRW administration is safe and may have an alkalizing effect in young physically active men.

Authors:

Chunxiang Xia, Wenwu Liu, Dongxiao Zeng, Xue Jun Sun

Publication:

Clinical and Translational Science, Oct 2013

Summary:

HRW significantly attenuates oxidative stress in CHB patients, but further study with long-term treatment is required to confirm the effect of HRW on liver function and HBV DNA level.

Authors:

Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa,Yuichi Hara, Yuji Naritomi, Hiroshi Hara and Tetsuhiko Nagao

Publication:

Medical Gas Research, Sep 2012

Summary:

The results suggest that the hydroxyl radical scavenger H2 effectively reduces oxidative stress in patients with this condition. The symptoms of RA were significantly improved with high H2 water.

Author:

Ann Otol Rhinol Laryngol

Publication:

Journal of the International Society of Sports Nutrition, Jul 2012

Summary:

Unlike conventional drinking water, pH 8.8 alkaline water instantly denatures pepsin, rendering it permanently inactive. In addition, it has good acid-buffering capacity. Thus, the consumption of alkaline water may have therapeutic benefits for patients with reflux disease.

Authors:

Medical Gas Research, Jul 2012

Publication:

Journal of the International Society of Sports Nutrition, Jul 2012

Summary:

Adequate hydration with hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function. Although further studies to elucidate the exact mechanisms and the benefits are needed to be confirmed in larger series of studies, these preliminary results may suggest that HW may be suitable hydration for athletes.

Authors:

Yusheng Zhao, Ping Li, Ling Ge, Yan Wang, Ting Mo, Xinping Zeng, Xiaodan Wang

Publication:

Elsevier Food Chemistry, Apr 2012

Summary:

The effect of electrolyzed reduced water (ERW) on enantiomeric theanine and polyphenols in tea was explored. There was no change of theanine, but rather a loss of ECG (epicatechin gallate) and an increasing amount of GA (gallic acid). ERW also reduced tea cream, which contains significant amount of polyphenols, indicating its potential application in the tea-beverage industry.

Authors:

Sanetaka Shirahata Takeki, Hamasaki, Kiichiro Teruya

Publication:

Kyushu University, Japan, Nov 2011

Summary:

Accumulating evidence has shown that reduced waters are health beneficial and they suppress oxidative stress-related diseases such as diabetes, cancer, arteriosclerosis, neurodegenerative diseases, and the side effects of haemodialysis. The mechanisms of action of reduced water for scavenging ROS are considered to be complicated. ERW contains hydrogen molecules and mineral nanoparticles. Hydrogen molecules and active hydrogen may be new redox regulation factors that can induce the gene expression of antioxidative enzymes. Hydrogen molecules may be converted to active hydrogen by catalyst action of metal nanoparticles to exhibit more potent reducibility. Mineral nanoparticles themselves are new types of multi-functional antioxidants.

Authors:

Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, Nakao A.

Publication:

Medical Gas Research, Jun 2011

Summary:

Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen- rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumour effects.

Authors:

Sergej M. Ostojic, Marko D. Stojanovic, Julio Calleja-Gonzalez, Milos D.

Publication:

Serbian Ministry of Science, Jan 2011

Summary:

This is the first approach to understand the NORP effect in athletes. Intake of a NORP formulation for one week seems to increase serum bicarbonates and reduce the rate of blood lactate accumulation during exercise, maximal rate of perceived exertion and cardiovascular stress at critical running velocity with no significant adverse effects.

Authors:

Masaaki Nakayama, Hirofumi Nakano, Hiromi Hamada, Noritomo Itami, RyoichiNakazawa and Sadayoshi Ito

Publication:

Nephrology Dialysis Transplantation, Sep 2010

Summary:

Adding H2 to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

Authors:

Kuo-Chin Huang, Shih-Ping Hsu, Chih-Ching Yang, Pu Ou-Yang, Kun-Tai Lee, Shinkatsu Morisawa, Kazumichi Otsubo and Chiang-Ting Chien

Publication:

Nephrology Dialysis Transplantation, Aug 2010

Summary:

One-year ERW treatment effectively ameliorated T-cell apoptosis, altered CD25- related surface markers and intracellular cytokine profile in the HD patients.

Authors:

Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans and Najla Guthrie

Publication:

Journal of Clinical Biochemistry and Nutrition, Mar 2010

Summary:

In conclusion, consumption of hydrogen rich water generated via a magnesium stick demonstrated improvement in the levels of oxidative stress markers associated with metabolic syndrome and boosted the body’s antioxidant activity. Hydrogen rich water represents a potentially novel therapeutic and preventive strategy for the treatment of metabolic syndrome. This method of delivery was advantageous as magnesium sticks are portable and proved to be an easy and safe administration of hydrogen rich water for daily consumption.

Authors:

Alvah C Bittner, Rachel C. L. Bittner, K. Lile, Yoshihide Sakuragi

Publication:

Human Factors and Ergonomics Society Annual Meeting Proceedings, Oct 2017

Summary:

This study both: (1) tested the effects of MSW ultra-negative-ion water on aerobic performance; and (2) partially evaluated the utility of an I2E: Unified-Model (Bittner & Sakuragi, 2006). Swim-team volunteers were accessed double-blind over 4 days following a MPPM or PMMP Schedule. Analyses, adjusted and unadjusted for carryover, revealed significant increases in 600s lap-swim distance and associated aerobic output. Lap-time analyses indicated emerging increases within the first 100yds) and between 1st and 2nd. It is concluded that (1) MSW Neg.-Ion Water increased 10 min. lap-swimming aerobic output by ≥13.2% - pointing to potential for substantial performance increases in athletes and older-workers, as well as V02-Max challenged retirees, and (2) this unprecedented increase supported predictions of the Bittner-Sakuragi Unified Model.

Authors:

K.-C. Huang, C.-C. Yang, S.-P. Hsu, K.-T. Lee, H.-W. Liu, S. Morisawa, K. Otsubo, C.-T. Chief

Publication:

Kidney International, International Society of Nephrology, Jul 2006

Summary:

In conclusion, ERW treatment administration is effective in palliating HD-evoked oxidative stress, as indicated by lipid peroxidation, haemolysis, and overexpression of proinflammatory cytokines in HD patients.

Authors:

Ryuhei Nishikawa, Kiichiro Teruya, Yoshinori Katakura, Kazuhiro Osada, Takeki Hamasaki, Taichi Kashiwagi, Takaaki Komatsu, Yuping Li, Jun Ye

Publication:

Springer Cytotechnology, Feb 2005

Summary:

ERW supplemented with Pt nps suppressed transformation at the promoter stage, not at initiation, suggesting that ERW supplemented with Pt nps suppressed the PMA-induced augmentation of intracellular ROS. ERW supplemented with Pt nps is a potential new antioxidant against carcinogenesis.

Authors:

Kuo-Chin Huang, Chih-Ching Yang, Kun-Tai Lee and Chiang-Ting Chien

Publication:

Kuo-Chin Huang, Chih-Ching Yang, Kun-Tai Lee and Chiang-Ting Chien

Summary:

This study demonstrates that haemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defence and reduce H2O2- and HOCl-induced oxidative stress.

Authors:

Vormann J, Worlitschek M, Goedecke T, Silver B.

Publication:

Journal of Trace Elements in Medicine and Biology, Jan 2001

Summary:

The results show that a disturbed acid-base balance may contribute to the symptoms of low back pain. The simple and safe addition of an alkaline multimineral preparate was able to reduce the pain symptoms in these patients with chronic low back pain.

Authors:

Sanetaka Shirahata, Shigeru Kabayama, Mariko Nakano, Takumi Miura

Publication:

Biochemical and Biophysical Research Communications, Jun 1997

Summary:

Reduced water suppresses single-strand breakage of DNA b active oxygen species produced by the Cu (II)-catalyzed oxidation of ascorbic acid in a dose-dependent manner, suggesting that reduced water can scavenge not only O2.- and H2O2, but also 1O2 and. OH. Electrolyzed Reduced Water Scavenges Active Oxygen Species and Protects DNA from Oxidative Damage